Task-Specific Experience and Task-Specific Talent: Decomposing the Productivity of High School Teachers

We use administrative panel data to decompose worker performance into components relating to general talent, task-specific talent, general experience, and task-specific experience. We consider the context of high school teachers, in which tasks consist of teaching particular subjects in particular tracks. Using the timing of changes in the subjects and levels to which teachers are assigned to provide identifying variation, we show that much of the productivity gains to teacher experience estimated in the literature are actually subject-specific. By contrast, very little of the variation in the permanent component of productivity among teachers is subject-specific or level-specific. Counterfactual simulations suggest that maximizing the value of task-specific experience could produce nearly costless efficiency gains on the order of .02 test score standard deviations

Measuring eccentricity in binary black-hole initial data

Initial data for evolving black-hole binaries can be constructed via many techniques, and can represent a wide range of physical scenarios. However, because of the way that different schemes parameterize the physical aspects of a configuration, it is not alway clear what a given set of initial data actually represents. This is especially important for quasiequilibrium data constructed using the conformal thin-sandwich approach. Most initial-data studies have focused on identifying data sets that represent binaries in quasi-circular orbits. In this paper, we consider initial-data sets representing equal-mass black holes binaries in eccentric orbits. We will show that effective-potential techniques can be used to calibrate initial data for black-hole binaries in eccentric orbits. We will also examine several different approaches, including post-Newtonian diagnostics, for measuring the eccentricity of an orbit. Finally, we propose the use of the ``Komar-mass difference'' as a useful, invariant means of parameterizing the eccentricity of relativistic orbits.Comment: 12 pages, 11 figures, submitted to Physical Review D, revtex

Ethanol alters the GABAergic neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP or allopregnanolone) at local brain sites: significance of local 3α,5α-THP increases in the ventral tegmental area

Neuroactive steroids are endogenous modulators of neuronal activity that modulate central nervous system inhibitory tone and influence motivation and emotional behaviors. The inhibitory neuroactive steroid (3a,5a)-3-hydroxypregnan-20-one (3α,5α-THP or allopregnanolone) is a potent positive modulator of γ-aminobutyric acid type A (GABAA) receptors. In rats, systemic ethanol administration increases 3α,5α-THP in the blood plasma, cerebral cortex, and hippocampus. Ethanol-induced increases of 3α,5α-THP contribute to the behavioral and neurophysiological effects of ethanol in rats and the subjective effects of alcohol in humans. Previous in vivo studies suggest that ethanol-induced increases of 3α,5α-THP are dependent on the adrenal glands, but in vitro studies suggest ethanol produces local synthesis of 3α,5α-THP. Furthermore, limitations in steroid assays have prevented the study of ethanol-induced changes of 3α,5α-THP in many of the brain regions implicated in alcoholism. The first aim of this project used 3α,5α-THP immunohistochemistry (IHC) to determine ethanol effects on cellular levels of 3α,5α-THP across the rat brain, and determine the role of the adrenal glands in these effects. We showed that ethanol produces divergent, brain region specific, effects on cellular 3α,5α-THP levels. We also showed that ethanol can increase or decrease local iv brain levels of 3α,5α-THP independent of adrenal activation in subcortical brain regions, but increases of 3α,5α-THP in the medial prefrontal cortex (mPFC) are dependent on the adrenal glands. Previous studies have shown that systemic 3α,5α-THP can reduce ethanol reinforcement and consumption. However, systemic 3α,5α-THP is metabolized rapidly and can produce sedation, limiting therapeutic value. Therefore, in aim 2 we used gene delivery to drive local neuroactive steroid synthesis in the nucleus accumbens (NAc) or ventral tegmental area (VTA), which are both implicated in ethanol reinforcement and consumption. We showed that adeno-associated viral vector-mediated local increases of 3α,5α-THP in the VTA were associated with a long-term reduction in ethanol reinforcement and consumption. Further investigation showed that 3α,5α-THP is located in tyrosine hydroxylase (TH) positive and negative neurons, but not astrocytes in the VTA. These studies showed that ethanol can produce divergent effects on local brain levels of 3α,5α-THP and increasing local levels of 3α,5α-THP in the VTA is associated with reduced ethanol reinforcement and consumption.Doctor of Philosoph

Circular orbits and spin in black-hole initial data

The construction of initial data for black-hole binaries usually involves the choice of free parameters that define the spins of the black holes and essentially the eccentricity of the orbit. Such parameters must be chosen carefully to yield initial data with the desired physical properties. In this paper, we examine these choices in detail for the quasiequilibrium method coupled to apparent-horizon/quasiequilibrium boundary conditions. First, we compare two independent criteria for choosing the orbital frequency, the "Komar-mass condition" and the "effective-potential method," and find excellent agreement. Second, we implement quasi-local measures of the spin of the individual holes, calibrate these with corotating binaries, and revisit the construction of non-spinning black hole binaries. Higher-order effects, beyond those considered in earlier work, turn out to be important. Without those, supposedly non-spinning black holes have appreciable quasi-local spin; furthermore, the Komar-mass condition and effective potential method agree only when these higher-order effects are taken into account. We compute a new sequence of quasi-circular orbits for non-spinning black-hole binaries, and determine the innermost stable circular orbit of this sequence.Comment: 24 pages, 17 figures, accepted for publication in Physical Review D, revtex4; Fixed error in computing proper separation and updated figures and tables accordingly, added reference to Sec. IV.A, fixed minor error in Sec. IV.B, added new data to Tables IV and V, fixed 1 reference, fixed error in Eq. (A7b), included minor changes from PRD editin

Impacts of an extreme cyclone event on landscape-scale savanna fire, productivity and greenhouse gas emissions

North Australian tropical savanna accounts for 12% of the world\u27s total savanna land cover. Accordingly, understanding processes that govern carbon, water and energy exchange within this biome is critical to global carbon and water budgeting. Climate and disturbances drive ecosystem carbon dynamics. Savanna ecosystems of the coastal and sub-coastal of north Australia experience a unique combination of climatic extremes and are in a state of near constant disturbance from fire events (1 in 3 years), storms resulting in windthrow (1 in 5–10 years) and mega-cyclones (1 in 500–1000 years). Critically, these disturbances occur over large areas creating a spatial and temporal mosaic of carbon sources and sinks. We quantify the impact on gross primary productivity (GPP) and fire occurrence from a tropical mega-cyclone, tropical Cyclone Monica (TC Monica), which affected 10 400 km2 of savanna across north Australia, resulting in the mortality and severe structural damage to ~140 million trees. We estimate a net carbon equivalent emission of 43 Tg of CO2-e using the moderate resolution imaging spectroradiometer (MODIS) GPP (MOD17A2) to quantify spatial and temporal patterns pre- and post-TC Monica. GPP was suppressed for four years after the event, equivalent to a loss of GPP of 0.5 Tg C over this period. On-ground fuel loads were estimated to potentially release 51.2 Mt CO2-e, equivalent to ~10% of Australia\u27s accountable greenhouse gas emissions. We present a simple carbon balance to examine the relative importance of frequency versus impact for a number of key disturbance processes such as fire, termite consumption and intense but infrequent mega-cyclones. Our estimates suggested that fire and termite consumption had a larger impact on Net Biome Productivity than infrequent mega-cyclones. We demonstrate the importance of understanding how climate variability and disturbance impacts savanna dynamics in the context of the increasing interest in using savanna landscapes for enhanced carbon sinks in emission offset schemes

Chalcogen Impact on Covalency within Molecular [Cu\u3csub\u3e3\u3c/sub\u3e(μ\u3csub\u3e3\u3c/sub\u3e-E)]\u3csup\u3e3+\u3c/sup\u3e Clusters (E = O, S, Se): A Synthetic, Spectroscopic, and Computational Study

Reaction of the tricopper(I)-dinitrogen tris(β-diketiminate) cyclophane, Cu3(N2)L, with O-atom-transfer reagents or elemental Se affords the oxido-bridged tricopper complex Cu3(μ3-O)L (2) or the corresponding Cu3(μ3-Se)L (4), respectively. For 2 and 4, incorporation of the bridging chalcogen donor was supported by electrospray ionization mass spectrometry and K-edge X-ray absorption spectroscopy (XAS) data. Cu L2,3-edge X-ray absorption data quantify 49.5% Cu 3d character in the lowest unoccupied molecular orbital of 2, with Cu 3d participation decreasing to 33.0% in 4 and 40.8% in the related sulfide cluster Cu3(μ3-S)L (3). Multiedge XAS and UV/visible/near-IR spectra are employed to benchmark density functional theory calculations, which describe the copper-chalcogen interactions as highly covalent across the series of [Cu3(μ-E)]3+ clusters. This result highlights that the metal-ligand covalency is not reserved for more formally oxidized metal centers (i.e., CuIII + O2- vs CuII + O-) but rather is a significant contributor even at more typical ligand-field cases (i.e., Cu3II/II/I + E2-). This bonding is reminiscent of that observed in p-block elements rather than in early-transition-metal complexes

Ethanol Administration Produces Divergent Changes in GABAergic Neuroactive Steroid Immunohistochemistry in the Rat Brain

The 5α-reduced pregnane neuroactive steroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP or allopregnanolone) is a potent positive modulator of GABAA receptors capable of modulating neuronal activity. In rats, systemic ethanol administration increases cerebral cortical and hippocampal levels of 3α,5α-THP, but the effects of ethanol on 3α,5α-THP levels in other brain regions are unknown. There is a large body of evidence suggesting that 3α,5α-THP enhances ethanol sensitivity, contributes to some behavioral effects of ethanol, and modulates ethanol reinforcement and motivation to drink. In the present study, we used immunohistochemistry (IHC) to determine ethanol-induced changes in cellular 3α,5α-THP expression in brain regions associated with ethanol actions and responses

Overexpression of the Steroidogenic Enzyme Cytochrome P450 Side Chain Cleavage in the Ventral Tegmental Area Increases 3 ,5 -THP and Reduces Long-Term Operant Ethanol Self-Administration

Neuroactive steroids are endogenous neuromodulators capable of altering neuronal activity and behavior. In rodents, systemic administration of endogenous or synthetic neuroactive steroids reduces ethanol self-administration. We hypothesized this effect arises from actions within mesolimbic brain regions that we targeted by viral gene delivery. Cytochrome P450 side chain cleavage (P450scc) converts cholesterol to pregnenolone, the rate-limiting enzymatic reaction in neurosteroidogenesis. Therefore, we constructed a recombinant adeno-associated serotype 2 viral vector (rAAV2), which drives P450scc expression and neuroactive steroid synthesis. The P450scc-expressing vector (rAAV2-P450scc) or control GFP-expressing vector (rAAV2-GFP) were injected bilaterally into the ventral tegmental area (VTA) or nucleus accumbens (NAc) of alcohol preferring (P) rats trained to self-administer ethanol. P450scc overexpression in the VTA significantly reduced ethanol self-administration by 20% over the 3 week test period. P450scc overexpression in the NAc, however, did not alter ethanol self-administration. Locomotor activity was unaltered by vector administration to either region. P450scc overexpression produced a 36% increase in (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP, allopregnanolone)-positive cells in the VTA, but did not increase 3α,5α-THP immunoreactivity in NAc. These results suggest that P450scc overexpression and the resultant increase of 3α,5α-THP-positive cells in the VTA reduces ethanol reinforcement. 3α,5α-THP is localized to neurons in the VTA, including tyrosine hydroxylase neurons, but not astrocytes. Overall, the results demonstrate that using gene delivery to modulate neuroactive steroids shows promise for examining the neuronal mechanisms of moderate ethanol drinking, which could be extended to other behavioral paradigms and neuropsychiatric patholog

Evidence from neurolinguistic methodologies: can it actually inform linguistic/ language acquisition theories and translate to evidence-based applications?

This special issue is a testament to the recent burgeoning interest by theoretical linguists, language acquisitionists and teaching practitioners in the neuroscience of language. It offers a highly valuable, state-of-the-art overview of the neurophysiological methods that are currently being applied to questions in the field of second language (L2) acquisition, teaching and processing. Research in the area of neurolinguistics has developed dramatically in the past twenty years, providing a wealth of exciting findings, many of which are discussed in the papers in this volume. The goal of this commentary is twofold. The first is to critically assess the current state of neurolinguistic data from the point of view of language acquisition and processing—informed by the papers that comprise this special issue and the literature as a whole—pondering how the neuroscience of language/processing might inform us with respect to linguistic and language acquisition theories. The second goal is to offer some links from implications of exploring the first goal towards informing language teachers and the creation of linguistically and neurolinguistically-informed evidence-based pedagogies for non-native language teaching

Tuberculosis Microepidemics among Dispersed Migrants, Birmingham, UK, 2004-2013

MIRU-VNTR typing was supported by the Public Health England National TB Strain Typing Project. M.M. is funded by the UK Clinical Research Collaboration Modernising Medical Microbiology Consortium. C.B. is funded by the Heart of Birmingham Primary Care Trust and Public Health England